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corneal ulcer/protease
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Serum albumin, serum antiproteases and polymorphonuclear leucocyte neutral collagenolytic protease in the tear fluid of patients with corneal ulcers.
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Using a micro-electroimmune assay, the concentration of polymorphonuclear leucocyte neutral collagenolytic protease, serum-albumin, alpha-1-antitrypsin and alpha-2-macroglobulin were measured in the tear fluid from 18 eyes of 16 patients with severe, melting corneal ulcers. By this method, PML-c-ase
Serum antiproteases and polymorphonuclear leucocyte neutral collagenolytic protease in the tear fluid of patients with corneal ulcers treated with n-butylcyano acrylate glue.
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Four patients with central melting perforating corneal ulcers were treated by n-butylcyano acrylate gluing of the ulcer region. The glue facilitated healing of the eyes, and when the glue scaled off weeks later the corneas were left with stable leucomas. The glue membrane appears to prevent
Therapeutic effect of immunization with OEP, protease toxoid and elastase toxoid on corneal ulcers in mice due to Pseudomonas aeruginosa infection.
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The effectiveness of immunizing mice with protease toxoid (PT) or elastase toxoid (ET) on the corneal ulcerization due to either protease or elastase were investigated. Consequently, mice immunized with either PT or ET were protected from corneal ulcers experimentally induced by the homologous
Corneal ulcers caused by protease and elastase from Pseudomonas aeruginosa.
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Effect of phosphoramidon on protection against corneal ulcer caused by elastase and protease from Pseudomonas aeruginosa.
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Effects of immunization of horses with common antigen (OEP), protease toxoid, and elastase toxoid on corneal ulceration due to Pseudomonas aeruginosa infection.
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Environmentally Endemic Pseudomonas aeruginosa Strains with Mutations in lasR Are Associated with Increased Disease Severity in Corneal Ulcers.
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The Steroids for Corneal Ulcers Trial (SCUT) was a multicenter, international study of bacterial keratitis in which 101 Pseudomonas aeruginosa infections were treated. Twenty-two of 101 P. aeruginosa isolates collected had a colony morphology characteristic of a loss-of-function mutation in lasR,
A Pseudomonas aeruginosa strain isolated from a contact lens-induced acute red eye (CLARE) is protease-deficient.
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OBJECTIVE
Pseudomonas aeruginosa proteases are thought to be important virulence factors in the pathogenesis of corneal disease. This study examined protease production from two strains of P. aeruginosa responsible for two very distinct clinical diseases: strain Paer1, isolated from a Contact
Krill protease effects on wound healing after corneal alkali burn.
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OBJECTIVE
To study the effect of a novel protease in the development and progression of corneal ulceration secondary to alkali burning.
METHODS
By using a 4N alkali burn model of corneal ulceration in rabbits, the effects and efficacy of topical application of a novel protease (PHM-101) capable of
Purification and characterization of four proteases from a clinical isolate of Serratia marcescens kums 3958.
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Four distinct proteases were purified to homogeneity from culture filtrates of Serratia marcescens kums 3958, a fresh isolate from a patient with a severe corneal ulcer. Purification was achieved by ammonium sulfate precipitation, DEAE-cellulose ion-exchange chromatography, and Sephadex gel
PAS-positive polymorphonuclear leucocytes in corneal ulcers.
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Fifty consecutive cases of severe keratitis with clinical signs of corneal ulcers were examined histologically for stage of inflammatory reaction. Further, 14 similar cases were studied ultrastructurally. Cell counts of polymorphonuclears (PML), eosinophils, lymphocytes and plasma cells were carried
Effect of protease inhibitors on corneal epithelial migration.
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Recently protease inhibitors were used to treat corneal ulceration and persistent epithelial defect. An organ culture system was used in this study to examine the effect of four protease inhibitors on rat corneal epithelial migration and on incorporation of 3H-leucine into trichloroacetic
Histochemical changes in the rabbit cornea and plasmin activity in the tear fluid during contact lens wear. Favourable influence of protease inhibitors (aprotinin, PC5, elastatinal).
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Plasmin activity in the tear fluid of the rabbit eye was examined during the wearing of soft contact lenses (SCL) and compared with the occurrence of corneal disturbances assessed in cryostat sections. Plasmin activity was determined with a semiquantitative method using dry punches of filter paper
Evaluation of various compounds to inhibit activity of matrix metalloproteinases in the tear film of horses with ulcerative keratitis.
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OBJECTIVE
To examine in vitro effects of various antiproteolytic compounds on activity of matrix metalloproteinase (MMP)-2 and -9 in the tear film of horses with active corneal ulcers.
METHODS
Samples of tear film obtained from the eyes of 34 horses with active ulcerative keratitis.
METHODS
Horses
Modulation of proteolytic activity associated with persistent corneal ulcers in dogs.
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Canines affected with corneal lesions demonstrate increased proteolytic activity at the affected site. Canines that develop persistent corneal ulcers and maintain elevated levels of proteolytic activity respond to protease inhibitor therapy with polysulpated glycosaminoglycan, PSGAG. In this study,
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