Tick-borne Encephalitis and Possible Borrelial Serology
キーワード
概要
日付
最終確認済み: | 04/30/2019 |
最初に提出された: | 05/16/2019 |
提出された推定登録数: | 05/16/2019 |
最初の投稿: | 05/20/2019 |
最終更新が送信されました: | 05/16/2019 |
最終更新日: | 05/20/2019 |
実際の研究開始日: | 12/31/2006 |
一次完了予定日: | 12/30/2013 |
研究完了予定日: | 12/30/2013 |
状態または病気
介入/治療
Drug: Anti-borrelial antibiotic therapy
Other: No antibiotics
段階
アームグループ
腕 | 介入/治療 |
---|---|
Anti-borrelial antibiotic therapy | Drug: Anti-borrelial antibiotic therapy Beside symptomatic therapy, patients received oral doxycycline 100 mg (Doxy®) twice daily or ceftriaxone 2 g (Lendacin®) once daily for 14 days. Antibiotic therapy was left to the discretion of treating physicians. Patients reported the presence of nonspecific symptoms such as headache, fatigue, arthralgia, myalgia. |
No antibiotics Patients who received symptomatic therapy (paracetamol, Lekadol®, granisetron, Kytril®, metamizol, Analgin®, parenteral hydration with saline). Patients reported the presence of nonspecific symptoms such as headache, fatigue, arthralgia, myalgia. | Other: No antibiotics Patients who received symptomatic therapy (paracetamol, Lekadol®, granisetron, Kytril®, metamizol, Analgin®, parenteral hydration with saline). Patients reported the presence of nonspecific symptoms such as headache, fatigue, arthralgia, myalgia. |
適格基準
研究の対象となる年齢 | 18 Years に 18 Years |
研究に適格な性別 | All |
サンプリング方法 | Non-Probability Sample |
健康なボランティアを受け入れる | はい |
基準 | Inclusion Criteria: - age ≥18 years - admitted between January 2007 and December 2013 at the University Medical Centre Ljubljana, Slovenia - tick-borne encephalitis defined according to European criteria (febrile illness with symptoms and/or signs of meningitis or meningoencephalitis, cerebrospinal fluid (CSF) pleocytosis (>5 × 106 cells/L), and demonstration of acute TBE virus infection (the presence of specific tick-borne encephalitis virus IgM and IgG antibodies in serum or demonstration of intrathecal production of specific TBE virus IgM and/or IgG antibodies in patients previously vaccinated against tick-borne encephalitis) Exclusion Criteria: - Lyme borreliosis in the past |
結果
主な結果の測定
1. Number of patients with objective manifestations of Lyme borreliosis [up to 12 months follow-up]
2. Frequency of nonspecific symptoms such as headache, fatigue, arthralgia, myalgia [up to 12 months follow-up]