Tohoku Journal of Experimental Medicine 1980-Oct
Mechanism of the development of resistance to mitomycin C in Hirosaki sarcoma.
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概要
In the peritoneal cavity of the rat, Hirosaki sarcoma, as ascites tumor of the rat, acquired a resistance to the essentially effective dose of 100 microgram/kg of mitomycin C by means of the daily treatment with the ineffective dose of 10 or 1 microgram/kg of mitomycin C. It is considered that most of Hirosaki sarcoma cells may have gradually acquired a hereditary resistance to mitomycin C in the course of the contact with the drug.