Evidence-based Complementary and Alternative Medicine 2018
Screening of Plants Used as Traditional Anticancer Remedies in Mkuranga and Same Districts, Tanzania, Using Brine Shrimp Toxicity Bioassay.
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概要
Methods This study was a single disease ethnomedical enquiry focusing on plants being used for cancer treatment
Face-to-face interviews and questionnaires were administered to eight (8) THPs in Mkuranga and Same districts on the claimed plants and their use for management of cancer. Plants were selected based on being frequently mentioned and emphasis given by THPs. Literature search and brine shrimp toxicity (BST) of methanol : dichloromethane (1:1) extracts was used as surrogates to evaluate strength of the claims.Results
This study reports 25 plant species used by the THPs in two districts of Tanzania. Eight plants (32%) have been reported in the literature to have activity against cancer cells. BST results revealed, 14 (56%) plants exhibited high toxicity against brine shrimps. The most active plants included Croton pseudopulchellus Pax (LC50 4.2 μg/ml), Dalbergia melanoxylon Guill. & Perr. (LC50 6.8 μg/ml), Loranthus micranthus Linn (LC50 4.0 μg/ml), Ochna mossambicensis Klotzsch (LC50 3.3 μg/ml), and Spirostachys africana Sond. (LC50 4.4 μg/ml); their toxicity was comparable to that of Catharanthus roseus (L) G. Don. (LC50 6.7 μg/ml), an established source of anticancer compounds. Nine other plants had LC50 values between (19.8 and 71.6) μg/ml, indicating also potential to yield anticancer.