[The study of apoptosis of hepatocytes of rats for estimation safety and efficacy of application biologically active substances].

The magnitude of apoptosis of hepatocytes of rats that were within 2 weeks on a balanced complete semi-synthetic diet supplemented with extract of green tea, epigallocatechin gallate (EGCG), quercetin, coffein (1-4th experimental groups accordingly) is studied. The contents EGCG, quercetin and coffein in rats of 2-4th experimental groups correspond to their content in diet of rats 1 experimental group, and equally contents in tonic beverage. It is determined that application in diets extract of green tea and its compounds does not damage effect on hepatocytes of rats. The use of diets with the inclusion of extract of green tea, quercetin and coffein provides the clear tendency to stabilize the plasma membrane of hepatocytes comparison with rats of control group (rats fed the same diet but without the inclusion of the above-mentioned biologically active substances).