Molecular Nutrition and Food Research 2020-Feb
Influence of Diet-Induced Obesity on the Bioavailability and Metabolism of Raspberry Ketone (4-(4-Hydroxyphenyl)-2-Butanone) in Mice.
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RESULTS
RK was rapidly absorbed (Tmax ∼15 min), deposited in brain and bioconverted into diverse metabolites in mice. Total bioavailability (AUC0-12 h ) was slightly lower in females than males (566 vs. 675 nmol/mL*min). Total bioavailability in obese mice was almost doubled that of control mice (1197 vs. 679 nmol/mL*min), while peaking times and elimination half-lives were delayed. Higher levels of RK and major metabolites were found in WAT of the obese than normal-weight animals.