[Research Advance on Reversing Multidrug Resistance of Chronic Myeloid Leukemia by Chinese Herbal Monomer--Review]

Abstract Chronic myeloid leukemia (CML) is a malignant myeloproliferative tumor which is originating from hematopoietic stem cells. Chemotherapy is the preferred made of treatment for the disease. However, in recent years, more and more patients have multidrug resistance (MDR) during treatment, which is the main cause of failure treatment, therefore, the search for effective reversal agents has important clinical significance. Traditional Chinese medicine derived reversal agents have the characteristics of multiple targets, low toxicity and high efficiency, which can reverse the drug resistance through different mechanisms, and the research potential is unlimited. In recent years, it has been widely concerned by scholars at home and abroad, especially the research on physcion, emodin, curcumin, matrine, gambogic acid, oridonin, ligustrazine, solanine and other monomers, which has made great advance. In this reviwe, the recent research advance on the reversal of MDR in chronic myeloid leukemia by Chinese medicine monomer is summarized briefly.

题目: 中药单体逆转慢性髓系白血病多药耐药的研究进展.

摘要: 摘要 慢性髓系白血病（CML）是一种起源于造血干细胞的恶性骨髓增生性肿瘤。化疗是该病首选的治疗方式，但近年来越来越多的患者在治疗中出现多药耐药（multidrug resistance，MDR），这是导致治疗失败的主要原因，因此寻找有效逆转剂对临床具有重要的意义。中药逆转剂具有多靶点、低毒、高效等特点，其可以通过不同的机制逆转耐药，具有无限的研究潜能，近几年受到了国内外学者的广泛关注，特别是对大黄素甲醚、大黄素、姜黄素、苦参碱、藤黄酸、冬凌草甲素、川芎嗪、龙葵碱等单体的研究有不少进展。本文就近年来中药单体逆转慢性髓系白血病MDR的最新研究进展作一综述.