succinate dehydrogenase/кровотечение

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Activation of hypoxia-inducible factor -1α via succinate dehydrogenase pathway during acute lung injury induced by trauma/hemorrhagic shock.

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Hypoxia-inducible factor (HIF)-1α is a transcription factor that is critical for tissue adaption to hypoxia and inflammation. Previous studies had indicated that normoxic activation of HIF-1α in cancer involves inhibition or mutation of the metabolic enzyme succinate dehydrogenase (SDH). We have

Diazoxide, as a postconditioning and delayed preconditioning trigger, increases HSP25 and HSP70 in the central nervous system following combined cerebral stroke and hemorrhagic shock.

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Combined hemorrhagic shock (Shock) and unilateral common carotid artery occlusion (Stroke) results in a decrease of oxygen availability to peripheral tissues and organs and the central nervous system (CNS). A variety of biochemical processes ensue, including organ failure, cellular apoptosis, and

Bioenergetics of different brain areas after experimental subarachnoid hemorrhage in rats.

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We studied energy metabolism after experimental subarachnoid hemorrhage in rats. Four different cerebral areas were tested: frontal cortex, occipital cortex, hippocampus, and brainstem. Vmax of the following enzymatic activities was evaluated: in the homogenate: hexokinase, phosphofructokinase, and

[Use of succinate dehydrogenase activity of lymphocytes to predict the course of the post-resuscitation period].

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The enzyme status of lymphocytes was studied in experiments on white male rats revived after a 4-min clinical death due to acute blood loss. It is established that the initial status of lymphocyte succinate dehydrogenase is essential for predicting cytochemical pattern and peculiarities of

MDCT features of succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumours.

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OBJECTIVE To describe the multidetector CT (MDCT) features and metastatic pattern of succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumours (GISTs). METHODS In this institutional review board-approved, Health Insurance Portability and Accountability Act-compliant study, we

[Prognostic value of determining the succinate dehydrogenase activity of lymphocytes and the therapeutic effectiveness of sodium succinate in resuscitation of rats].

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In the experiments on male rats recovered after clinical death caused by acute hemorrhage and mechanical asphyxia undulatory changes of lymphocyte succinate dehydrogenase activity were revealed: enzyme inhibition during clinical death, activation in the first minutes of resuscitation with subsequent

Succinate dehydrogenase mutant of Listonella anguillarum protects rainbow trout against vibriosis.

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Listonella anguillarum is a Gram-negative facultative anaerobic rod causing hemorrhagic septicemia in marine and rarely in freshwater fish. Succinate dehydrogenase (SDH) plays an important role in the tricarboxylic acid (TCA) cycle by oxidizing succinate to fumarate while reducing ubiquinone to

Effects of seawater immersion on the functions of mitochondria of myocardium and hepatocyte in hemorrhagic shock rats.

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OBJECTIVE To investigate the effects of seawater immersion on the function of myocardium and hepatocyte mitochondria in experimental hemorrhagic shock rats. METHODS Twenty-four male Wistar rats were divided into three groups (n=8 in each group): control group, HSL group (hemorrhagic shock group on

[Characteristics of thrombocyte metabolism in puerperae with massive blood loss and gestosis and possible ways of its metabolic correction].

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Succinate dehydrogenase, phospholipid and glycogen activities were measured by cytochemical methods in puerperae with massive blood loss in the presence of gestosis in order to investigate platelet metabolism and the possible approaches to metabolic correction. A significant depression of platelet

Malignant paraganglioma presenting with hemorrhagic stroke in a child.

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Sympathetic paragangliomas are rare catecholamine-secreting tumors of extra-adrenal origin, and their diagnosis in children is even more infrequent. They usually manifest as hypertension, palpitations, headache, sweating, and pallor. Malignant paragangliomas are identified by the presence of

Experimental isobaric subarachnoid hemorrhage: regional mitochondrial function during the acute and late phase.

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Patients treated for aneurysmal subarachnoid hemorrhage show, in the long-term follow up, an elevated rate of cognitive disturbances that are mainly related to the impact of the initial bleeding: the neurotoxic effects of blood deposition in subarachnoidal spaces may result in a diffuse

Fibrinolysis and aspiration of experimental intracerebral hematoma reduces the volume of ischemic brain in rats.

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The hypothesis was tested in rats that brain ischemia by an intracerebral hematoma can be ameliorated by fibrinolysis and aspiration of the hematoma. Intraparenchymal blood clots were generated by the injection of 50 microliters of autologous blood into the right caudate nucleus in two portions

Diazoxide increases liver and kidney HSP25 and HSP70 after shock and stroke.

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BACKGROUND The compound, diazoxide (DZ), is known to induce preconditioning through its effect as a mitochondrial K(ATP) channel opener and succinate dehydrogenase inhibitor. Our team tested the hypothesis that pharmacological induction of ischemic preconditioning with DZ can offer cytoprotection

Paraganglioma of the Vagina Associated With Germline SDHB Mutation: Report of a Case With Review of the Literature.

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Paragangliomas are rare neuroendocrine neoplasms in the vagina, and their molecular pathogenesis has not been documented. We report a case of vaginal paraganglioma in a 15-yr-old adolescent girl who presented with irregular heavy menses and anemic symptoms. Examination under anesthesia revealed a

[Shock: concepts for a definition].

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The shock syndrome has been classically considered as a consequence of both decreased tissue perfusion and O2 supply; however, in some types of shock like septic or traumatic ones, regional blood flows may be increased. A decade ago, mitochondrial alterations consistent with uncoupling of oxidative

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