[Plasma amino acid concentrations and isoleucine-phenylalanine quotient in patients with acute myocardial infarct during amino acid infusion].
Maneno muhimu
Kikemikali
OBJECTIVE
The influence of substitution with two different amino acid solutions on changes in plasma amino acids were studied in patients with acute myocardial infarction.
METHODS
Thirty consecutive patients admitted to an intensive care unit were included in this open, nonrandomized study. The isoleucine-phenylalanine-concentration ratio was calculated. Patients of the treatment groups received 10 ml/kg BW/24 h of 10% amino acid solutions intravenously (1 g/kg BW/24 h). Patients of group 1 received Intrafusin 10%, patients of group 2 Aminosteril 10%. Ten patients (group 3) were infused with 10 ml/kg BW/24 h isotonic electrolyte solution (Jonosteril and served as a control group. All infusions were performed over a 96 hour period.
RESULTS
All infusion of amino acid solutions increased the plasma concentrations of most amino acids without a significant impact on the pattern of amino acids over time. Significant increases in plasma concentrations together with a significant variation over time were observed for glycine, isoleucine, proline, alpha-amino-butyric-acid and glutamine. A significant difference in relation to the type of amino acid solution was observed for isoleucine and proline (rapid increase and higher concentrations with Aminosteril), and glutamine (rapid increase and higher levels with Intrafusin).
CONCLUSIONS
The isoleucine-phenylalanine-ratio increased from initially decreased values between 0.9 and 1.0 during amino acid infusion and reached the level of 1.25 found in healthy persons in patients with Intrafusin infusions.
