Evaluation of Melatonin Application of Immediate Dental Implant
キーワード
概要
説明
Melatonin is chemically recognized as N-acetyl-5-methoxytryptamine. It is a compound occurring naturally in plants, microbes and animals. The circulating level of the melatonin hormone in animals shows interesting variations, by entertainment of variable biological functions in a daily cycle "circadian rhythm". Melatonin called hormone of night is secreted by the pineal gland, and its plasma levels concentration are 50 folds higher in night in comparison to daytime. A variety of peripheral cells play a role in production of melatonin such as epithelial cells, bone marrow cells, and lymphocytes. Though melatonin is a hormone, it does not act on a specific organ, it has several functions; stimulation of the synthesis of type I collagen fibers, regulation of the body temperature, sexual development, antioxidant scavenging and detoxifying free radicals thus inhibiting the process of bone resorption through interfering with the function of osteoclasts.
日付
| 最終確認済み: | 12/31/2019 |
| 最初に提出された: | 09/25/2018 |
| 提出された推定登録数: | 09/26/2018 |
| 最初の投稿: | 09/30/2018 |
| 最終更新が送信されました: | 01/25/2020 |
| 最終更新日: | 01/27/2020 |
| 実際の研究開始日: | 09/29/2019 |
| 一次完了予定日: | 09/29/2020 |
| 研究完了予定日: | 12/29/2020 |
状態または病気
介入/治療
Device: immediate implant placement
Drug: implant placement with melatonine
段階
アームグループ
| 腕 | 介入/治療 |
|---|---|
| Experimental: implant placement with melatonine immediate implant placement with melatonine | Drug: implant placement with melatonine topical application of melatonin |
| Active Comparator: immediate implant placement alone immediate implant placement alone |
適格基準
| 研究の対象となる年齢 | 18 Years に 18 Years |
| 研究に適格な性別 | All |
| 健康なボランティアを受け入れる | はい |
| 基準 | Inclusion criteria 1. Age: 18-60. 2. Healthy patients 3. Non Smoker 4. Patients with adequate bone volume for immediate dental implant procedure. 5. Patients with absence of any periapical pathosis. Exclusion criteria: 1. Heavy smokers. 2. Systemic disease that contraindicates implant placement or surgical procedures. 3. No or poor patient's compliance. 4. Psychological problems. 5. Pathology at the site of intervention. 6. Pregnancy females. 7. Patient refuses to sign the informed consent. |
結果
主な結果の測定
1. implant stability [6 months]
二次的な結果の測定
1. Soft tissue healing [10 days]
2. Post operative pain [10 days]
