"Old remedies to heal the liver: novel effects of digoxin in hepatic sterile inflammation".

The hepatic inflammatory response is one of the main driving forces of disease progression in chronic liver diseases mainly by promoting a sustained hepatic fibrogenesis, which can lead to cirrhosis (1). Thus, reducing persistent inflammatory activity over time is an important goal of therapy as it may abrogate disease progression. Important advances have been made over the past decade in the understanding of the molecular pathways and cellular players involved in liver inflammation. In particular, a more detailed knowledge of the underlying mechanisms of initiation and perpetuation of sterile inflammation have shed light on the pathophysiology of both alcoholic steatohepatitis (ASH) and non-alcoholic steatohepatitis (NASH) (2), which are by far the most common causes of liver disease in industrialized countries, and are major causes of morbidity and mortality worldwide This article is protected by copyright. All rights reserved.