The Effects of Rhus Coriaria L. on Serum Lipid Levels of Patients With Hyperlipidemia
キーワード
概要
説明
Rhus (Somagh) is found in temperate and tropical regions worldwide, often growing in areas of marginal agricultural capacity. Rhus is used as an herbal remedy in traditional medicine because of its assumed analgesic, antidiarrhetic, antiseptic, anorexic and antihypergylcemic properties. The fruits of Rhus contain flavonols, phenolic acids, hydrolysable tannins, anthocyans and organic acids such as malice, citric and tartaric acids. Some studies have shown that polyphenols could have beneficial effects on cardiovascular disease and cancer and could be regarded as bioactive compounds with a high potential health-promoting capacity. Phenolic compounds inhibit lipid peroxidation, scavenge the superoxide anion and hydroxyl radical, and enhance the activities of detoxifying enzymes.Moreover, the hypocholesterolemic action of dietary polyphenols has been reported. The hypocholesterolemic effect of Rhus fruit powder and its components have been reported previously in rabbits and mice.
日付
最終確認済み: | 05/31/2016 |
最初に提出された: | 11/09/2014 |
提出された推定登録数: | 11/16/2014 |
最初の投稿: | 11/19/2014 |
最終更新が送信されました: | 06/03/2016 |
最終更新日: | 06/06/2016 |
実際の研究開始日: | 11/30/2014 |
一次完了予定日: | 03/31/2015 |
研究完了予定日: | 04/30/2015 |
状態または病気
介入/治療
Drug: Rhus
Drug: Placebo
段階
アームグループ
腕 | 介入/治療 |
---|---|
Experimental: Rhus 500 mg of Rhus Coriaria L. (Rhus) powder in capsule: 1 capsule twice daily for 6 weeks | Drug: Rhus 500 mg of Rhus Coriaria L. (Rhus) powder in capsule: 1 capsule twice daily for 6 weeks |
Placebo Comparator: Placebo Placebo capsule: 1 capsule twice daily for 6 weeks | Drug: Placebo Placebo capsule: 1 capsule twice daily for 6 weeks |
適格基準
研究の対象となる年齢 | 20 Years に 20 Years |
研究に適格な性別 | All |
健康なボランティアを受け入れる | はい |
基準 | Inclusion Criteria: - Age: 20-65 years - Serum triglyceride >150mg/dl AND/OR total cholesterol >= 240mg/dl Exclusion Criteria: - Serum triglyceride > 500 mg/dl - Serum LDL-cholesterol at level which need drug treatment according to the patient risk categories (NCEP-ATP III) - Diabetes mellitus - Hypo. or hyperthyroidism - Any systemic illnesses e.g. liver cirrhosis, acute or chronic renal failure, heart failure - Use of drugs: OCPs, lipid lowering agents, thiazides - Pregnancy - Alcoholism - History of allergic reaction to Somagh |
結果
主な結果の測定
1. Serum total cholesterol level [6 weeks]
2. Serum triglyceride level [6 weeks]
3. Serum HDL-cholesterol level [6 weeks]
二次的な結果の測定
1. Serum LDL-cholesterol level [6 weeks]
2. Fasting Blood Sugar (FBS) [6 weeks]
3. Serum creatinin level [6 weeks]
4. Serum ALT level [6 weeks]
5. Serum AST level [6 weeks]
6. Serum alkaline phosphatase level [6 weeks]
7. Number of patients with adverse events [10 weeks]