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The Effects of Rhus Coriaria L. on Serum Lipid Levels of Patients With Hyperlipidemia

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Shiraz University of Medical Sciences

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概要

Coronary heart disease and stroke are two main causes of human deaths and is directly related to increased levels of plasma lipids.High total cholesterol and low high density lipoprotein cholesterol concentrations are often associated with endothelium dysfunction and inflammation, which can be followed by atherosclerosis.
Rhus coriaria L. (Rhus) with the public name of "Somagh" is a plant species in the anacardiaceae family that is used as a food supplement, spice in Middle East region (Iran, Turkey and Arabic countries).
In a double blind randomized placebo-controlled clinical trial, the investigators want to evaluate the effects of Somagh (Rhus coriaria L.) on serum lipid levels of patients with hyperlipidemia.

説明

Rhus (Somagh) is found in temperate and tropical regions worldwide, often growing in areas of marginal agricultural capacity. Rhus is used as an herbal remedy in traditional medicine because of its assumed analgesic, antidiarrhetic, antiseptic, anorexic and antihypergylcemic properties. The fruits of Rhus contain flavonols, phenolic acids, hydrolysable tannins, anthocyans and organic acids such as malice, citric and tartaric acids. Some studies have shown that polyphenols could have beneficial effects on cardiovascular disease and cancer and could be regarded as bioactive compounds with a high potential health-promoting capacity. Phenolic compounds inhibit lipid peroxidation, scavenge the superoxide anion and hydroxyl radical, and enhance the activities of detoxifying enzymes.Moreover, the hypocholesterolemic action of dietary polyphenols has been reported. The hypocholesterolemic effect of Rhus fruit powder and its components have been reported previously in rabbits and mice.

日付

最終確認済み: 05/31/2016
最初に提出された: 11/09/2014
提出された推定登録数: 11/16/2014
最初の投稿: 11/19/2014
最終更新が送信されました: 06/03/2016
最終更新日: 06/06/2016
実際の研究開始日: 11/30/2014
一次完了予定日: 03/31/2015
研究完了予定日: 04/30/2015

状態または病気

Hyperlipidemias

介入/治療

Drug: Rhus

Drug: Placebo

段階

-

アームグループ

介入/治療
Experimental: Rhus
500 mg of Rhus Coriaria L. (Rhus) powder in capsule: 1 capsule twice daily for 6 weeks
Drug: Rhus
500 mg of Rhus Coriaria L. (Rhus) powder in capsule: 1 capsule twice daily for 6 weeks
Placebo Comparator: Placebo
Placebo capsule: 1 capsule twice daily for 6 weeks
Drug: Placebo
Placebo capsule: 1 capsule twice daily for 6 weeks

適格基準

研究の対象となる年齢 20 Years に 20 Years
研究に適格な性別All
健康なボランティアを受け入れるはい
基準

Inclusion Criteria:

- Age: 20-65 years

- Serum triglyceride >150mg/dl AND/OR total cholesterol >= 240mg/dl

Exclusion Criteria:

- Serum triglyceride > 500 mg/dl

- Serum LDL-cholesterol at level which need drug treatment according to the patient risk categories (NCEP-ATP III)

- Diabetes mellitus

- Hypo. or hyperthyroidism

- Any systemic illnesses e.g. liver cirrhosis, acute or chronic renal failure, heart failure

- Use of drugs: OCPs, lipid lowering agents, thiazides

- Pregnancy

- Alcoholism

- History of allergic reaction to Somagh

結果

主な結果の測定

1. Serum total cholesterol level [6 weeks]

2. Serum triglyceride level [6 weeks]

3. Serum HDL-cholesterol level [6 weeks]

二次的な結果の測定

1. Serum LDL-cholesterol level [6 weeks]

2. Fasting Blood Sugar (FBS) [6 weeks]

3. Serum creatinin level [6 weeks]

4. Serum ALT level [6 weeks]

5. Serum AST level [6 weeks]

6. Serum alkaline phosphatase level [6 weeks]

7. Number of patients with adverse events [10 weeks]

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